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OphtaPRIME® – The 3-in-1 prequel to ocular treatment


Why use OphtaPRIME® ?

With its unique formulation, OphtaPRIME® provides a 3-in-1 preparatory, ocular solution.

Tris and EDTA are common components within topical ear preparations.

Their role is well established in the management of otitis externa. Until now, there has been no equivalent product for ocular infections.

  • Polysorbate 80 is a surfactant and emulsifier1

  • Clears organic debris and crusts from the ocular and periocular surfaces


  • Tris EDTA is a well-known ion-chelating agent

  • Removes membrane-stabilising ions – destabilising biofilms and exposing bacteria2,3


  • Tris EDTA destabilises bacterial outer cell walls

  • Increases bacterial cell permeability to antimicrobials2,3,4

Where to use OphtaPRIME®?

OphtaPRIME® prepares the eye and facilitates the action of certain ocular treatments. Thus, it is best used prior to topical medications.

Topical antibiotics are routinely prescribed in the below ocular conditions, and therefore OphtaPRIME® can be an option to complement the treatment(s):

  • Corneal Ulceration (Ulcerative keratitis)

  • Immunemediated disease

  • Conjunctivitis

  • Blepharitis

  • Orbital/Periorbital disease

  • Post-surgery

How OphtaPRIME® can help?

Bacterial infection is a primary concern for many ocular disorders and the risk of complication is high with uncontrolled infection.

OphtaPRIME® facilitates ocular treatments.

Secondary bacterial overgrowth or infection is a common complication.

OphtaPRIME® breaks down biofilms and aids restoration of normal flora.

Frequent, intermittent use of antibiotics increases the risk of resistance and treatment failure.

OphtaPRIME® facilitates the action of ocular treatments, reducing this risk.

How to use OphtaPRIME®?

  • Apply 5 minutes prior to an ocular treatment.

  • Apply 1 to 2 drops into the affected eye.

  • OphtaPRIME® is designed to be a preparatory solution.

  • It is not designed for use as a daily cleaner.

1. accessed 25/01/2024. 2. Banin, E; Brady, KM.; Greenberg, EP (2006) Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm. Applied and environmental microbiology 72(3);2064-2069. DOI: 10.1128/AEM.72.3.2064-2069.2006. 3. Boyd, M; Santoro, D; Gram, D (2019) In vitro antimicrobial activity of topical ontological antimicrobials and Tris-EDTA against resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa isolates from dogs. Veterinary Dermatology 30(2);139-e40. DOI: 10.1111/vde.12717. 4. Wooley, RE; Jones, MS; Shotts, EB (1984) Uptake of antibiotics in gram-negative bacteria exposed to EDTA-Tris. Veterinary microbiology 10(1);57-70. DOI: 10.1016/0378-1135(84)90056-7.